Drug interactions
Nilotinib + Tadalafil
Severity: Minor
Nilotinib and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a weak to moderate CYP3A4 inhibitor and may increase tadalafil exposure. Nilotinib also prolongs the QT interval, but tadalafil is not a major QT concern, so the main issue is tadalafil adverse effects.
What this interaction means in plain words
Nilotinib and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nilotinib belongs to Oncology; Tadalafil belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated tadalafil metabolism by nilotinib.
What to do
No empiric dose adjustment is required. Monitor for hypotension, headache and flushing and reduce tadalafil if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nilotinib and Tadalafil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Tadalafil?
MediHelp rates the interaction as minor. Nilotinib and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib is a weak to moderate CYP3A4 inhibitor and may increase tadalafil exposure. Nilotinib also prolongs the QT interval, but tadalafil is not a major QT concern, so the main issue is tadalafil adverse effects.
How serious is the interaction between Nilotinib and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose adjustment is required. Monitor for hypotension, headache and flushing and reduce tadalafil if they occur.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
