Drug interactions
Nilotinib + Trastuzumab
Severity: Moderate
Nilotinib and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can contribute to myelosuppression and infection risk, and trastuzumab can cause cardiomyopathy while nilotinib prolongs QT. The combination is uncommon and the interaction is largely additive toxicity.
What this interaction means in plain words
Nilotinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic toxicity, including hematologic and cardiac effects; no pharmacokinetic interaction is established.
What to do
Monitor complete blood counts and signs of infection, and assess cardiac function and ECG regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Nilotinib with Trastuzumab?
MediHelp rates the interaction as moderate. Nilotinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can contribute to myelosuppression and infection risk, and trastuzumab can cause cardiomyopathy while nilotinib prolongs QT. The combination is uncommon and the interaction is largely additive toxicity.
How serious is the interaction between Nilotinib and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of infection, and assess cardiac function and ECG regularly.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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