Drug interactions
Nilotinib + Triamcinolone
Severity: Moderate
Nilotinib and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may raise triamcinolone exposure, increasing the risk of systemic corticosteroid effects such as Cushingoid features and adrenal suppression.
What this interaction means in plain words
Nilotinib and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Triamcinolone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated triamcinolone metabolism by nilotinib.
What to do
Monitor for signs of corticosteroid excess with repeated or high-dose triamcinolone. Consider a lower dose or a less CYP3A4-dependent steroid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Triamcinolone?
MediHelp rates the interaction as moderate. Nilotinib and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may raise triamcinolone exposure, increasing the risk of systemic corticosteroid effects such as Cushingoid features and adrenal suppression.
How serious is the interaction between Nilotinib and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess with repeated or high-dose triamcinolone. Consider a lower dose or a less CYP3A4-dependent steroid.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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