Drug interactions
Nimodipine + Nitroglycerin rectal
Severity: Moderate
Nimodipine and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Organic nitrates and calcium channel blockers both vasodilate and can cause additive hypotension and orthostasis. Rectal nitroglycerin is absorbed systemically, so the interaction is relevant.
What this interaction means in plain words
Nimodipine and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from nitric oxide-mediated venodilation and calcium channel blockade.
What to do
Monitor blood pressure and warn the patient about orthostatic symptoms. Lower the dose of either drug if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nimodipine and Nitroglycerin rectal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Nimodipine with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Nimodipine and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Organic nitrates and calcium channel blockers both vasodilate and can cause additive hypotension and orthostasis. Rectal nitroglycerin is absorbed systemically, so the interaction is relevant.
How serious is the interaction between Nimodipine and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and warn the patient about orthostatic symptoms. Lower the dose of either drug if hypotension occurs.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
