Drug interactions
Nimodipine + Nitroglycerin sublingual
Severity: Moderate
Nimodipine and Nitroglycerin sublingual: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower vascular tone, so using them together can produce additive hypotension, including marked orthostatic falls in blood pressure. This may cause dizziness, syncope or reduced cerebral and coronary perfusion, particularly in older patients.
What this interaction means in plain words
Nimodipine and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through calcium channel blockade (nimodipine) and nitric oxide-mediated smooth muscle relaxation (nitroglycerin).
What to do
Monitor blood pressure, especially on standing, and advise patients to sit before taking sublingual nitroglycerin. Reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Nimodipine with Nitroglycerin sublingual?
MediHelp rates the interaction as moderate. Nimodipine and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower vascular tone, so using them together can produce additive hypotension, including marked orthostatic falls in blood pressure. This may cause dizziness, syncope or reduced cerebral and coronary perfusion, particularly in older patients.
How serious is the interaction between Nimodipine and Nitroglycerin sublingual?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially on standing, and advise patients to sit before taking sublingual nitroglycerin. Reduce doses if symptomatic hypotension occurs.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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