Drug interactions
Nirmatrelvir + Zidovudine
Severity: Minor
Nirmatrelvir and Zidovudine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirmatrelvir given with ritonavir may modestly lower zidovudine exposure, likely by induction of glucuronidation. The effect is generally small and the short COVID-19 treatment course limits its relevance.
What this interaction means in plain words
Nirmatrelvir and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nirmatrelvir belongs to Anti Virals; Zidovudine belongs to Anti Virals.
Why it happens
Ritonavir may induce glucuronidation of zidovudine; the mechanism is not firmly established.
What to do
No dose change is generally required for a five-day course. Continue routine HIV viral load monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nirmatrelvir and Zidovudine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Nirmatrelvir
- Alfuzosin + Nirmatrelvir Contraindicated
- Amiodarone + Nirmatrelvir Contraindicated
- Apalutamide + Nirmatrelvir Contraindicated
- Carbamazepine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Dronedarone + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Nirmatrelvir with Zidovudine?
MediHelp rates the interaction as minor. Nirmatrelvir and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nirmatrelvir given with ritonavir may modestly lower zidovudine exposure, likely by induction of glucuronidation. The effect is generally small and the short COVID-19 treatment course limits its relevance.
How serious is the interaction between Nirmatrelvir and Zidovudine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required for a five-day course. Continue routine HIV viral load monitoring.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
