Drug interactions
Nirogacestat + Sertraline
Severity: Minor
Nirogacestat and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirogacestat is metabolised by CYP3A4, and moderate or strong inhibitors increase its exposure and adverse effects such as diarrhoea and hepatotoxicity. Sertraline is only a weak CYP3A4 inhibitor, so any increase is probably small.
What this interaction means in plain words
Nirogacestat and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nirogacestat belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline reducing nirogacestat clearance.
What to do
No dose adjustment is required; monitor for diarrhoea and liver enzymes. Avoid adding stronger CYP3A4 inhibitors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nirogacestat and Sertraline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Nirogacestat
Frequently asked questions
Can I take Nirogacestat with Sertraline?
MediHelp rates the interaction as minor. Nirogacestat and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nirogacestat is metabolised by CYP3A4, and moderate or strong inhibitors increase its exposure and adverse effects such as diarrhoea and hepatotoxicity. Sertraline is only a weak CYP3A4 inhibitor, so any increase is probably small.
How serious is the interaction between Nirogacestat and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for diarrhoea and liver enzymes. Avoid adding stronger CYP3A4 inhibitors.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
