Drug interactions
Nitrendipine + Verapamil
Severity: Moderate
Nitrendipine and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and may raise nitrendipine levels, leading to excess vasodilation. Two calcium channel blockers also have additive blood pressure lowering effects.
What this interaction means in plain words
Nitrendipine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by verapamil reducing nitrendipine metabolism, plus additive calcium channel blockade.
What to do
Monitor blood pressure and for edema, flushing or headache; lower the nitrendipine dose if hypotension occurs, or avoid dual therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Nitrendipine with Verapamil?
MediHelp rates the interaction as moderate. Nitrendipine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits CYP3A4 and may raise nitrendipine levels, leading to excess vasodilation. Two calcium channel blockers also have additive blood pressure lowering effects.
How serious is the interaction between Nitrendipine and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema, flushing or headache; lower the nitrendipine dose if hypotension occurs, or avoid dual therapy.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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