Drug interactions
nitroglycerin + tadalafil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Life-threatening hypotension due to additive vasodilation.
Mechanism of action
PDE5 inhibition + nitrate-mediated ↑cGMP.
Clinical management
Avoid; longer washout (≥48h) with tadalafil.
Drug reference
References
- Tadalafil – Label — FDA Label
- PDE5+nitrates — SPS
- Tadalafil nitrate interaction — PubMed
Frequently asked questions
Can I take nitroglycerin with tadalafil?
The interaction is rated: Contraindicated. Life-threatening hypotension due to additive vasodilation.
How serious is the interaction between nitroglycerin and tadalafil?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between nitroglycerin and tadalafil managed?
Avoid; longer washout (≥48h) with tadalafil.
Why do nitroglycerin and tadalafil interact?
PDE5 inhibition + nitrate-mediated ↑cGMP.
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