Drug interactions
Nitroglycerin rectal + Verapamil
Severity: Moderate
Nitroglycerin rectal and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil and nitrates both reduce blood pressure, and the combination can produce additive hypotension and orthostatic symptoms. The combination is often used in angina but needs attention to dose.
What this interaction means in plain words
Nitroglycerin rectal and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from calcium channel blockade and nitric oxide-mediated venous and arterial relaxation.
What to do
Monitor blood pressure and orthostatic symptoms, and advise slow position changes. Adjust the dose of either drug if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Nitroglycerin rectal with Verapamil?
MediHelp rates the interaction as moderate. Nitroglycerin rectal and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil and nitrates both reduce blood pressure, and the combination can produce additive hypotension and orthostatic symptoms. The combination is often used in angina but needs attention to dose.
How serious is the interaction between Nitroglycerin rectal and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and advise slow position changes. Adjust the dose of either drug if hypotension occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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