Drug interactions
Nitroglycerin sublingual + Vardenafil
Severity: Contraindicated
Nitroglycerin sublingual and Vardenafil: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual nitroglycerin taken after vardenafil may cause abrupt, severe hypotension. This is especially hazardous in patients with coronary disease.
What this interaction means in plain words
Nitroglycerin sublingual and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
PDE5 inhibition by vardenafil prevents cGMP breakdown, amplifying nitrate vasodilation.
What to do
Do not use within 24 hours of vardenafil. Advise patients to seek emergency care for chest pain rather than self-administer nitroglycerin after a dose.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Nitroglycerin sublingual with Vardenafil?
MediHelp rates the interaction as contraindicated. Nitroglycerin sublingual and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sublingual nitroglycerin taken after vardenafil may cause abrupt, severe hypotension. This is especially hazardous in patients with coronary disease.
How serious is the interaction between Nitroglycerin sublingual and Vardenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use within 24 hours of vardenafil. Advise patients to seek emergency care for chest pain rather than self-administer nitroglycerin after a dose.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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