Drug interactions
Nitroglycerin sublingual + Verapamil
Severity: Moderate
Nitroglycerin sublingual and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause vasodilation, and together they may produce symptomatic hypotension or orthostatic dizziness. The combination is often used intentionally in angina, but it still requires attention to blood pressure.
What this interaction means in plain words
Nitroglycerin sublingual and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure lowering.
What to do
Advise patients to sit when taking sublingual nitroglycerin and to rise slowly. Monitor blood pressure and adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Nitroglycerin sublingual with Verapamil?
MediHelp rates the interaction as moderate. Nitroglycerin sublingual and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause vasodilation, and together they may produce symptomatic hypotension or orthostatic dizziness. The combination is often used intentionally in angina, but it still requires attention to blood pressure.
How serious is the interaction between Nitroglycerin sublingual and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to sit when taking sublingual nitroglycerin and to rise slowly. Monitor blood pressure and adjust doses if symptomatic hypotension occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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