Drug interactions
Nitroprusside + Verapamil
Severity: Moderate
Nitroprusside and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may enhance the blood pressure lowering effect of nitroprusside, leading to excessive hypotension. Nitroprusside is given by titrated infusion, so effects are usually seen quickly.
What this interaction means in plain words
Nitroprusside and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilator and hypotensive effects.
What to do
Titrate the nitroprusside infusion against continuous blood pressure monitoring. Use lower starting infusion rates if verapamil is on board.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Nitroprusside with Verapamil?
MediHelp rates the interaction as moderate. Nitroprusside and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may enhance the blood pressure lowering effect of nitroprusside, leading to excessive hypotension. Nitroprusside is given by titrated infusion, so effects are usually seen quickly.
How serious is the interaction between Nitroprusside and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the nitroprusside infusion against continuous blood pressure monitoring. Use lower starting infusion rates if verapamil is on board.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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