Drug interactions
Nizatidine + Sofosbuvir / velpatasvir
Severity: Moderate
Nizatidine and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir dissolves poorly at higher pH, so acid suppression can lower its exposure and potentially reduce hepatitis C cure rates. The effect with H2 blockers is modest at low doses.
What this interaction means in plain words
Nizatidine and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Higher gastric pH decreases the pH-dependent solubility and absorption of velpatasvir.
What to do
Give the H2 blocker at the same time as, or 12 hours apart from, sofosbuvir/velpatasvir, keeping the dose at or below famotidine 40 mg twice daily equivalent. Avoid higher doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Frequently asked questions
Can I take Nizatidine with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Nizatidine and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir dissolves poorly at higher pH, so acid suppression can lower its exposure and potentially reduce hepatitis C cure rates. The effect with H2 blockers is modest at low doses.
How serious is the interaction between Nizatidine and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the H2 blocker at the same time as, or 12 hours apart from, sofosbuvir/velpatasvir, keeping the dose at or below famotidine 40 mg twice daily equivalent. Avoid higher doses.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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