Drug interactions
Norepinephrine + Procarbazine
Severity: Major
Norepinephrine and Procarbazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine inhibits MAO, which can enhance the pressor effect of norepinephrine. The result may be severe hypertension and arrhythmia, especially after a rapid infusion.
What this interaction means in plain words
Norepinephrine and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition reduces catecholamine metabolism and increases neuronal catecholamine stores, so the pressor response is potentiated.
What to do
Avoid if possible. If a vasopressor is essential, start at a much lower dose, titrate cautiously, and monitor blood pressure and ECG continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Norepinephrine with Procarbazine?
MediHelp rates the interaction as major. Norepinephrine and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine inhibits MAO, which can enhance the pressor effect of norepinephrine. The result may be severe hypertension and arrhythmia, especially after a rapid infusion.
How serious is the interaction between Norepinephrine and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If a vasopressor is essential, start at a much lower dose, titrate cautiously, and monitor blood pressure and ECG continuously.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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