Drug interactions
Norepinephrine + Tranylcypromine
Severity: Major
Norepinephrine and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective MAO inhibitors can exaggerate the pressor effect of norepinephrine. Severe hypertension and cardiovascular complications may result, particularly with infusions.
What this interaction means in plain words
Norepinephrine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition increases norepinephrine stores in sympathetic nerve terminals and enhances adrenergic responses.
What to do
Avoid unless essential. If a vasopressor is required, start at a much lower dose with continuous blood pressure monitoring, and have a short-acting antihypertensive available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Norepinephrine with Tranylcypromine?
MediHelp rates the interaction as major. Norepinephrine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nonselective MAO inhibitors can exaggerate the pressor effect of norepinephrine. Severe hypertension and cardiovascular complications may result, particularly with infusions.
How serious is the interaction between Norepinephrine and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless essential. If a vasopressor is required, start at a much lower dose with continuous blood pressure monitoring, and have a short-acting antihypertensive available.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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