Drug interactions
Nortriptyline + Palonosetron
Severity: Minor
Nortriptyline and Palonosetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rare serotonin syndrome reports exist for 5-HT3 antagonists combined with tricyclic antidepressants. Nortriptyline has modest serotonergic activity, so the risk is likely low.
What this interaction means in plain words
Nortriptyline and Palonosetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nortriptyline belongs to Central Nervous System; Palonosetron belongs to Gastrointestinal Tract.
Why it happens
Possible weak additive serotonergic effects; not firmly established.
What to do
No routine change needed; make patients aware of serotonin syndrome symptoms and reassess therapy if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Palonosetron
- Apomorphine + Palonosetron Contraindicated
- Isocarboxazid + Palonosetron Major
- Palonosetron + Phenelzine Major
- Palonosetron + Tranylcypromine Major
- Almotriptan + Palonosetron Moderate
- Amitriptyline + Palonosetron Moderate
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Palonosetron?
MediHelp rates the interaction as minor. Nortriptyline and Palonosetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rare serotonin syndrome reports exist for 5-HT3 antagonists combined with tricyclic antidepressants. Nortriptyline has modest serotonergic activity, so the risk is likely low.
How serious is the interaction between Nortriptyline and Palonosetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; make patients aware of serotonin syndrome symptoms and reassess therapy if they appear.
What other medicines interact with Palonosetron?
MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Isocarboxazid, Phenelzine. The full list is on the Palonosetron page.
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