Drug interactions
Nortriptyline + Scopolamine
Severity: Moderate
Nortriptyline and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combining them can add up to dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older adults and people with glaucoma, prostatic enlargement or cognitive impairment are most at risk.
What this interaction means in plain words
Nortriptyline and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity, especially delirium and urinary retention in elderly patients. Reduce the dose or choose a less anticholinergic option if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Scopolamine?
MediHelp rates the interaction as moderate. Nortriptyline and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combining them can add up to dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older adults and people with glaucoma, prostatic enlargement or cognitive impairment are most at risk.
How serious is the interaction between Nortriptyline and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially delirium and urinary retention in elderly patients. Reduce the dose or choose a less anticholinergic option if symptoms occur.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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