Drug interactions
Nortriptyline + Trospium
Severity: Moderate
Nortriptyline and Trospium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nortriptyline has considerable anticholinergic activity, which adds to the antimuscarinic effects of trospium. This can lead to dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, particularly in older adults.
What this interaction means in plain words
Nortriptyline and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Trospium belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects, especially in the elderly, and for cognitive changes and urinary retention. Consider a less anticholinergic antidepressant if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trospium
- Clozapine + Trospium Major
- Pramlintide + Trospium Major
- Thioridazine + Trospium Major
- Trihexyphenidyl + Trospium Major
- Aclidinium + Trospium Moderate
- Amantadine + Trospium Moderate
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Trospium?
MediHelp rates the interaction as moderate. Nortriptyline and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nortriptyline has considerable anticholinergic activity, which adds to the antimuscarinic effects of trospium. This can lead to dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, particularly in older adults.
How serious is the interaction between Nortriptyline and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially in the elderly, and for cognitive changes and urinary retention. Consider a less anticholinergic antidepressant if symptoms emerge.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
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