Drug interactions
Obinutuzumab + Ofatumumab sc
Severity: Major
Obinutuzumab and Ofatumumab sc: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are anti-CD20 antibodies that deplete B cells, so using them together adds immunosuppression and raises the risk of serious infections. Ofatumumab SC is used in multiple sclerosis, and overlap with obinutuzumab offers no recognised benefit.
What this interaction means in plain words
Obinutuzumab and Ofatumumab sc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CD20-mediated B-cell depletion causing cumulative immunosuppression.
What to do
Avoid concurrent use of these two anti-CD20 agents. When switching, allow for the duration of the prior drug's effect and monitor for infection and lymphocyte counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Obinutuzumab
Frequently asked questions
Can I take Obinutuzumab with Ofatumumab sc?
MediHelp rates the interaction as major. Obinutuzumab and Ofatumumab sc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are anti-CD20 antibodies that deplete B cells, so using them together adds immunosuppression and raises the risk of serious infections. Ofatumumab SC is used in multiple sclerosis, and overlap with obinutuzumab offers no recognised benefit.
How serious is the interaction between Obinutuzumab and Ofatumumab sc?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of these two anti-CD20 agents. When switching, allow for the duration of the prior drug's effect and monitor for infection and lymphocyte counts.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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