Drug interactions
Obinutuzumab + Rotavirus oral vaccine live
Severity: Major
Obinutuzumab and Rotavirus oral vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live rotavirus vaccine may cause prolonged vaccine-strain infection in immunosuppressed individuals, and obinutuzumab may reduce the vaccine response. This is mainly relevant for infants exposed to the drug, for example via maternal treatment.
What this interaction means in plain words
Obinutuzumab and Rotavirus oral vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
B-cell depletion impairs control of live attenuated virus and reduces vaccine immunogenicity.
What to do
Avoid live rotavirus vaccine while on obinutuzumab and until B-cell recovery. For infants exposed in utero, consider B-cell counts before live vaccination.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Obinutuzumab
Frequently asked questions
Can I take Obinutuzumab with Rotavirus oral vaccine live?
MediHelp rates the interaction as major. Obinutuzumab and Rotavirus oral vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Live rotavirus vaccine may cause prolonged vaccine-strain infection in immunosuppressed individuals, and obinutuzumab may reduce the vaccine response. This is mainly relevant for infants exposed to the drug, for example via maternal treatment.
How serious is the interaction between Obinutuzumab and Rotavirus oral vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live rotavirus vaccine while on obinutuzumab and until B-cell recovery. For infants exposed in utero, consider B-cell counts before live vaccination.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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