Drug interactions
Obinutuzumab + Smallpox vaccine live
Severity: Major
Obinutuzumab and Smallpox vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live vaccinia vaccine can cause progressive vaccinia and other serious complications in immunocompromised patients. Obinutuzumab-induced B-cell depletion increases this risk and weakens protection.
What this interaction means in plain words
Obinutuzumab and Smallpox vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Immunosuppression from B-cell depletion permits uncontrolled replication of live vaccinia virus.
What to do
Avoid live smallpox vaccine during obinutuzumab therapy and until B-cell recovery. Consider a non-replicating vaccine if one is available and indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Obinutuzumab
Frequently asked questions
Can I take Obinutuzumab with Smallpox vaccine live?
MediHelp rates the interaction as major. Obinutuzumab and Smallpox vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Live vaccinia vaccine can cause progressive vaccinia and other serious complications in immunocompromised patients. Obinutuzumab-induced B-cell depletion increases this risk and weakens protection.
How serious is the interaction between Obinutuzumab and Smallpox vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live smallpox vaccine during obinutuzumab therapy and until B-cell recovery. Consider a non-replicating vaccine if one is available and indicated.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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