Drug interactions
Obinutuzumab + Typhoid polysaccharide vaccine
Severity: Moderate
Obinutuzumab and Typhoid polysaccharide vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The Vi polysaccharide typhoid vaccine is inactivated, so there is no risk of vaccine infection. However, obinutuzumab B-cell depletion may substantially reduce the antibody response and leave the patient unprotected.
What this interaction means in plain words
Obinutuzumab and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
B-cell depletion impairs antibody production against vaccine antigens.
What to do
Give the vaccine at least 2 to 4 weeks before starting obinutuzumab where possible. If given during therapy, consider that protection may be inadequate and advise food and water precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Obinutuzumab
Frequently asked questions
Can I take Obinutuzumab with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as moderate. Obinutuzumab and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The Vi polysaccharide typhoid vaccine is inactivated, so there is no risk of vaccine infection. However, obinutuzumab B-cell depletion may substantially reduce the antibody response and leave the patient unprotected.
How serious is the interaction between Obinutuzumab and Typhoid polysaccharide vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 2 to 4 weeks before starting obinutuzumab where possible. If given during therapy, consider that protection may be inadequate and advise food and water precautions.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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