Drug interactions
Obinutuzumab + Typhoid vaccine live
Severity: Major
Obinutuzumab and Typhoid vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine contains attenuated Salmonella Typhi, which may cause invasive infection in immunocompromised patients. Obinutuzumab also reduces the vaccine response.
What this interaction means in plain words
Obinutuzumab and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Immunosuppression from B-cell depletion impairs control of live attenuated bacteria and vaccine response.
What to do
Avoid the live oral typhoid vaccine during obinutuzumab therapy; use the inactivated Vi polysaccharide vaccine instead. Give vaccines before treatment where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Obinutuzumab and Typhoid vaccine live, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Obinutuzumab
Frequently asked questions
Can I take Obinutuzumab with Typhoid vaccine live?
MediHelp rates the interaction as major. Obinutuzumab and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live typhoid vaccine contains attenuated Salmonella Typhi, which may cause invasive infection in immunocompromised patients. Obinutuzumab also reduces the vaccine response.
How serious is the interaction between Obinutuzumab and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live oral typhoid vaccine during obinutuzumab therapy; use the inactivated Vi polysaccharide vaccine instead. Give vaccines before treatment where possible.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
