Drug interactions
Obinutuzumab + Yellow fever vaccine
Severity: Major
Obinutuzumab and Yellow fever vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yellow fever vaccine is live attenuated, and in immunosuppressed patients it may cause serious vaccine-associated disease. Obinutuzumab also reduces the likelihood of an adequate immune response.
What this interaction means in plain words
Obinutuzumab and Yellow fever vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
B-cell depletion impairs control of live attenuated virus and vaccine immunogenicity.
What to do
Avoid yellow fever vaccination during treatment and until B-cell recovery. If travel to an endemic area is unavoidable, seek specialist advice and consider a medical exemption letter.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Obinutuzumab
Frequently asked questions
Can I take Obinutuzumab with Yellow fever vaccine?
MediHelp rates the interaction as major. Obinutuzumab and Yellow fever vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yellow fever vaccine is live attenuated, and in immunosuppressed patients it may cause serious vaccine-associated disease. Obinutuzumab also reduces the likelihood of an adequate immune response.
How serious is the interaction between Obinutuzumab and Yellow fever vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yellow fever vaccination during treatment and until B-cell recovery. If travel to an endemic area is unavoidable, seek specialist advice and consider a medical exemption letter.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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