Drug interactions
Obinutuzumab + Zoster vaccine live
Severity: Major
Obinutuzumab and Zoster vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live zoster vaccine may cause vaccine-strain varicella zoster infection in patients immunosuppressed by obinutuzumab, and the response may be inadequate.
What this interaction means in plain words
Obinutuzumab and Zoster vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
B-cell depletion impairs immunity to live attenuated virus.
What to do
Avoid live zoster vaccine during obinutuzumab therapy and until B-cell recovery. Use the recombinant zoster vaccine instead where indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Obinutuzumab and Zoster vaccine live, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Obinutuzumab
Frequently asked questions
Can I take Obinutuzumab with Zoster vaccine live?
MediHelp rates the interaction as major. Obinutuzumab and Zoster vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Live zoster vaccine may cause vaccine-strain varicella zoster infection in patients immunosuppressed by obinutuzumab, and the response may be inadequate.
How serious is the interaction between Obinutuzumab and Zoster vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live zoster vaccine during obinutuzumab therapy and until B-cell recovery. Use the recombinant zoster vaccine instead where indicated.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
