Drug interactions
Octreotide + Primaquine
Severity: Moderate
Octreotide and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and primaquine may also lengthen the QT interval. Combined use could increase arrhythmia risk, especially with bradycardia or electrolyte disturbance.
What this interaction means in plain words
Octreotide and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Primaquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with octreotide-related bradycardia further increasing susceptibility.
What to do
Obtain a baseline ECG and monitor heart rate and QTc during therapy. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Primaquine?
MediHelp rates the interaction as moderate. Octreotide and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and primaquine may also lengthen the QT interval. Combined use could increase arrhythmia risk, especially with bradycardia or electrolyte disturbance.
How serious is the interaction between Octreotide and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and QTc during therapy. Correct potassium and magnesium abnormalities.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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