Drug interactions
Octreotide + Quetiapine
Severity: Moderate
Octreotide and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, which may add to the QT effect of quetiapine. The combined risk of arrhythmia is greater in patients with other risk factors.
What this interaction means in plain words
Octreotide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization, with octreotide bradycardia further predisposing to arrhythmia.
What to do
Obtain a baseline ECG and monitor QTc and heart rate, particularly with electrolyte disturbances or heart disease. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Octreotide and Quetiapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Quetiapine?
MediHelp rates the interaction as moderate. Octreotide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, which may add to the QT effect of quetiapine. The combined risk of arrhythmia is greater in patients with other risk factors.
How serious is the interaction between Octreotide and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and heart rate, particularly with electrolyte disturbances or heart disease. Correct potassium and magnesium abnormalities.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
