Drug interactions
Octreotide + Quinidine
Severity: Moderate
Octreotide and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and quinidine adds to repolarization delay. The combination can raise the risk of torsades de pointes, particularly with bradycardia or electrolyte disturbance.
What this interaction means in plain words
Octreotide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with octreotide-related bradycardia increasing susceptibility.
What to do
Obtain a baseline ECG and monitor QTc and heart rate during co-therapy. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Quinidine?
MediHelp rates the interaction as moderate. Octreotide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and quinidine adds to repolarization delay. The combination can raise the risk of torsades de pointes, particularly with bradycardia or electrolyte disturbance.
How serious is the interaction between Octreotide and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and heart rate during co-therapy. Correct potassium and magnesium abnormalities.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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