Drug interactions
Octreotide + Quizartinib
Severity: Major
Octreotide and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib markedly prolongs the QT interval, and octreotide can add QT prolongation and bradycardia. The combination raises the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Octreotide and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Octreotide belongs to Endocrine; Quizartinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG frequently, especially at initiation and dose changes, and keep potassium and magnesium in the normal range. Reduce or interrupt quizartinib according to labeled QTc thresholds.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Octreotide
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Octreotide with Quizartinib?
MediHelp rates the interaction as major. Octreotide and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib markedly prolongs the QT interval, and octreotide can add QT prolongation and bradycardia. The combination raises the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Octreotide and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG frequently, especially at initiation and dose changes, and keep potassium and magnesium in the normal range. Reduce or interrupt quizartinib according to labeled QTc thresholds.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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