Drug interactions
Octreotide + Tetrabenazine
Severity: Moderate
Octreotide and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine causes dose-related QT prolongation. Combined with octreotide, which can cause bradycardia and conduction disturbances, the risk of ventricular arrhythmia may rise.
What this interaction means in plain words
Octreotide and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and electrolytes, particularly after dose increases of tetrabenazine. Avoid in patients with bradycardia, hypokalemia or congenital long QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Octreotide with Tetrabenazine?
MediHelp rates the interaction as moderate. Octreotide and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine causes dose-related QT prolongation. Combined with octreotide, which can cause bradycardia and conduction disturbances, the risk of ventricular arrhythmia may rise.
How serious is the interaction between Octreotide and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, particularly after dose increases of tetrabenazine. Avoid in patients with bradycardia, hypokalemia or congenital long QT.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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