Drug interactions
Octreotide + Voclosporin
Severity: Moderate
Octreotide and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin has been associated with QT prolongation at supratherapeutic exposure, and octreotide may add QT effects and bradycardia. Combined use may increase the chance of ventricular arrhythmia, especially with electrolyte abnormalities.
What this interaction means in plain words
Octreotide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT interval prolongation through pharmacodynamic effects.
What to do
Monitor ECG and serum electrolytes, especially potassium and magnesium. Reassess the combination if QTc prolongation or symptomatic bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Octreotide with Voclosporin?
MediHelp rates the interaction as moderate. Octreotide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin has been associated with QT prolongation at supratherapeutic exposure, and octreotide may add QT effects and bradycardia. Combined use may increase the chance of ventricular arrhythmia, especially with electrolyte abnormalities.
How serious is the interaction between Octreotide and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum electrolytes, especially potassium and magnesium. Reassess the combination if QTc prolongation or symptomatic bradycardia develops.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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