Drug interactions
Octreotide + Ziprasidone
Severity: Moderate
Octreotide and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and ziprasidone also lengthens the QT interval. The combination may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Octreotide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive QTc prolongation, with octreotide-induced bradycardia as a contributing factor.
What to do
Obtain a baseline ECG and monitor heart rate and QTc after starting or increasing octreotide. Keep potassium and magnesium normal and consider a lower-QT antipsychotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Ziprasidone?
MediHelp rates the interaction as moderate. Octreotide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and ziprasidone also lengthens the QT interval. The combination may increase the risk of ventricular arrhythmias.
How serious is the interaction between Octreotide and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and QTc after starting or increasing octreotide. Keep potassium and magnesium normal and consider a lower-QT antipsychotic.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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