Drug interactions
Odronextamab + Theophylline
Severity: Moderate
Odronextamab and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release after odronextamab can temporarily suppress CYP1A2 and raise theophylline concentrations. This may cause toxicity such as tachycardia, nausea and seizures.
What this interaction means in plain words
Odronextamab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Odronextamab belongs to Miscellaneous; Theophylline belongs to Respiratory.
Why it happens
Transient cytokine-mediated downregulation of CYP450 activity reduces theophylline metabolism.
What to do
Monitor serum theophylline concentrations during the first cycle and reduce the dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Odronextamab
- Cyclosporin + Odronextamab Moderate
- Odronextamab + Warfarin Moderate
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Odronextamab with Theophylline?
MediHelp rates the interaction as moderate. Odronextamab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release after odronextamab can temporarily suppress CYP1A2 and raise theophylline concentrations. This may cause toxicity such as tachycardia, nausea and seizures.
How serious is the interaction between Odronextamab and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum theophylline concentrations during the first cycle and reduce the dose if levels rise.
What other medicines interact with Odronextamab?
MediHelp also lists interactions of Odronextamab with, for example, Cyclosporin, Warfarin. The full list is on the Odronextamab page.
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