Drug interactions
Odronextamab + Warfarin
Severity: Moderate
Odronextamab and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release after odronextamab can temporarily suppress CYP450 enzymes and raise warfarin exposure. This may increase INR and bleeding risk, mainly in the first cycle.
What this interaction means in plain words
Odronextamab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Odronextamab belongs to Miscellaneous; Warfarin belongs to Cardiovascular.
Why it happens
Transient cytokine-mediated downregulation of CYP450 activity reduces warfarin metabolism.
What to do
Monitor INR more frequently during the first treatment cycle and adjust warfarin as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Odronextamab
- Cyclosporin + Odronextamab Moderate
- Odronextamab + Theophylline Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Odronextamab with Warfarin?
MediHelp rates the interaction as moderate. Odronextamab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release after odronextamab can temporarily suppress CYP450 enzymes and raise warfarin exposure. This may increase INR and bleeding risk, mainly in the first cycle.
How serious is the interaction between Odronextamab and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently during the first treatment cycle and adjust warfarin as needed.
What other medicines interact with Odronextamab?
MediHelp also lists interactions of Odronextamab with, for example, Cyclosporin, Theophylline. The full list is on the Odronextamab page.
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