Drug interactions
Cyclosporin + Odronextamab
Severity: Moderate
Cyclosporin and Odronextamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release after odronextamab can temporarily suppress CYP450 enzymes and raise cyclosporin levels. This may increase the risk of toxicity, mainly in the first cycle.
What this interaction means in plain words
Cyclosporin and Odronextamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Odronextamab belongs to Miscellaneous.
Why it happens
Transient cytokine-mediated downregulation of CYP3A activity reduces cyclosporin metabolism.
What to do
Monitor cyclosporin trough levels and renal function during the first cycle and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Odronextamab
- Odronextamab + Theophylline Moderate
- Odronextamab + Warfarin Moderate
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Odronextamab?
MediHelp rates the interaction as moderate. Cyclosporin and Odronextamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release after odronextamab can temporarily suppress CYP450 enzymes and raise cyclosporin levels. This may increase the risk of toxicity, mainly in the first cycle.
How serious is the interaction between Cyclosporin and Odronextamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporin trough levels and renal function during the first cycle and adjust the dose accordingly.
What other medicines interact with Odronextamab?
MediHelp also lists interactions of Odronextamab with, for example, Theophylline, Warfarin. The full list is on the Odronextamab page.
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