Drug interactions
Ofatumumab sc + Pneumococcal vaccine 13-valent
Severity: Moderate
Ofatumumab sc and Pneumococcal vaccine 13-valent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and can reduce antibody responses to vaccines. The inactivated pneumococcal vaccine is safe to give, but protection may be blunted if given during therapy.
What this interaction means in plain words
Ofatumumab sc and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anti-CD20 B-cell depletion reduces humoral response to vaccination.
What to do
Give inactivated vaccines at least 2 weeks before starting ofatumumab where possible. If given on treatment, consider checking antibody response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Ofatumumab sc with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as moderate. Ofatumumab sc and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and can reduce antibody responses to vaccines. The inactivated pneumococcal vaccine is safe to give, but protection may be blunted if given during therapy.
How serious is the interaction between Ofatumumab sc and Pneumococcal vaccine 13-valent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give inactivated vaccines at least 2 weeks before starting ofatumumab where possible. If given on treatment, consider checking antibody response.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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