Drug interactions
Ofatumumab sc + Prednisone
Severity: Moderate
Ofatumumab sc and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress immune function, so combined use may increase the risk of infection. Ofatumumab depletes B cells and the effect persists after the last dose.
What this interaction means in plain words
Ofatumumab sc and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and corticosteroid effects.
What to do
Screen for active infection and hepatitis B before treatment, and use the lowest effective steroid dose. Monitor for infections, and avoid live vaccines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Ofatumumab sc with Prednisone?
MediHelp rates the interaction as moderate. Ofatumumab sc and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress immune function, so combined use may increase the risk of infection. Ofatumumab depletes B cells and the effect persists after the last dose.
How serious is the interaction between Ofatumumab sc and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for active infection and hepatitis B before treatment, and use the lowest effective steroid dose. Monitor for infections, and avoid live vaccines.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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