Drug interactions
Ofatumumab sc + Procarbazine
Severity: Moderate
Ofatumumab sc and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is a myelosuppressive cytotoxic agent and ofatumumab depletes B cells, so combined use may increase immunosuppression. This raises the risk of serious or opportunistic infections. Ofatumumab SC is used for multiple sclerosis, so concurrent use would be unusual.
What this interaction means in plain words
Ofatumumab sc and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and cytotoxic bone marrow suppression.
What to do
Monitor blood counts and signs of infection, and consider delaying ofatumumab until chemotherapy-related immunosuppression has resolved. Check immunoglobulin levels and screen for hepatitis B before treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Ofatumumab sc with Procarbazine?
MediHelp rates the interaction as moderate. Ofatumumab sc and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine is a myelosuppressive cytotoxic agent and ofatumumab depletes B cells, so combined use may increase immunosuppression. This raises the risk of serious or opportunistic infections. Ofatumumab SC is used for multiple sclerosis, so concurrent use would be unusual.
How serious is the interaction between Ofatumumab sc and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of infection, and consider delaying ofatumumab until chemotherapy-related immunosuppression has resolved. Check immunoglobulin levels and screen for hepatitis B before treatment.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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