Drug interactions
Ofatumumab sc + Topotecan
Severity: Moderate
Ofatumumab sc and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs impair immune defences, ofatumumab through B-cell depletion and topotecan through myelosuppression. Together they may raise the risk of serious infections.
What this interaction means in plain words
Ofatumumab sc and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and cytotoxic bone marrow suppression.
What to do
Monitor for signs of infection and check blood counts and immunoglobulins. Consider the timing of ofatumumab initiation relative to the last chemotherapy cycle and recovery of counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Ofatumumab sc with Topotecan?
MediHelp rates the interaction as moderate. Ofatumumab sc and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs impair immune defences, ofatumumab through B-cell depletion and topotecan through myelosuppression. Together they may raise the risk of serious infections.
How serious is the interaction between Ofatumumab sc and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts and immunoglobulins. Consider the timing of ofatumumab initiation relative to the last chemotherapy cycle and recovery of counts.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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