Drug interactions
Ofatumumab sc + Ustekinumab
Severity: Moderate
Ofatumumab sc and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and ustekinumab modulates cytokine signaling, so the combination may increase susceptibility to infection. Combined use is not well studied.
What this interaction means in plain words
Ofatumumab sc and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and IL-12/23 blockade.
What to do
Avoid routine combination where possible, and monitor closely for infection if both are needed. Review active infection status before starting ofatumumab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Ofatumumab sc with Ustekinumab?
MediHelp rates the interaction as moderate. Ofatumumab sc and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and ustekinumab modulates cytokine signaling, so the combination may increase susceptibility to infection. Combined use is not well studied.
How serious is the interaction between Ofatumumab sc and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination where possible, and monitor closely for infection if both are needed. Review active infection status before starting ofatumumab.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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