Drug interactions
Ofloxacin + Paroxetine
Severity: Minor
Ofloxacin and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine has little QT-prolonging effect compared with other antidepressants, and ofloxacin has a modest one. Clinically significant additive risk is small except in patients with other risk factors.
What this interaction means in plain words
Ofloxacin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ofloxacin belongs to Anti Bacterial; Paroxetine belongs to Central Nervous System.
Why it happens
Possible small additive effect on cardiac repolarization.
What to do
No routine action is needed; check ECG and electrolytes only in patients with other QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Ofloxacin with Paroxetine?
MediHelp rates the interaction as minor. Ofloxacin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paroxetine has little QT-prolonging effect compared with other antidepressants, and ofloxacin has a modest one. Clinically significant additive risk is small except in patients with other risk factors.
How serious is the interaction between Ofloxacin and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check ECG and electrolytes only in patients with other QT risk factors.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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