Drug interactions
Ofloxacin + Sorafenib
Severity: Moderate
Ofloxacin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use may raise the risk of ventricular arrhythmias such as torsades de pointes. Electrolyte disturbances from cancer therapy can increase this risk.
What this interaction means in plain words
Ofloxacin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Sorafenib belongs to Oncology.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Repeat the ECG during combined therapy or choose a non-QT-prolonging antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Ofloxacin with Sorafenib?
MediHelp rates the interaction as moderate. Ofloxacin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so combined use may raise the risk of ventricular arrhythmias such as torsades de pointes. Electrolyte disturbances from cancer therapy can increase this risk.
How serious is the interaction between Ofloxacin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Repeat the ECG during combined therapy or choose a non-QT-prolonging antibiotic.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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