Drug interactions
Ofloxacin + Sunitinib
Severity: Moderate
Ofloxacin and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib prolongs the QT interval and ofloxacin can add to this effect. The combination may increase the risk of torsades de pointes, especially with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Ofloxacin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Sunitinib belongs to Oncology.
Why it happens
Additive delay of cardiac repolarization.
What to do
Perform a baseline and follow-up ECG and correct electrolyte deficits. Prefer an antibiotic without QT effects if one is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Ofloxacin with Sunitinib?
MediHelp rates the interaction as moderate. Ofloxacin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib prolongs the QT interval and ofloxacin can add to this effect. The combination may increase the risk of torsades de pointes, especially with electrolyte abnormalities or heart disease.
How serious is the interaction between Ofloxacin and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline and follow-up ECG and correct electrolyte deficits. Prefer an antibiotic without QT effects if one is suitable.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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