Drug interactions
Olanzapine + Oliceridine
Severity: Major
Olanzapine and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an opioid and olanzapine is a sedating antipsychotic. Together they can cause additive CNS and respiratory depression, with profound sedation, hypotension and in severe cases coma or death.
What this interaction means in plain words
Olanzapine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Olanzapine belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive central nervous system and respiratory depression through pharmacodynamic synergism.
What to do
Reserve the combination for patients with no adequate alternatives, using the lowest effective doses for the shortest duration. Monitor closely for sedation, respiratory depression and hypotension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Olanzapine
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Olanzapine with Oliceridine?
MediHelp rates the interaction as major. Olanzapine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is an opioid and olanzapine is a sedating antipsychotic. Together they can cause additive CNS and respiratory depression, with profound sedation, hypotension and in severe cases coma or death.
How serious is the interaction between Olanzapine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with no adequate alternatives, using the lowest effective doses for the shortest duration. Monitor closely for sedation, respiratory depression and hypotension.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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