Drug interactions
Olanzapine + Orphenadrin
Severity: Moderate
Olanzapine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is sedating and anticholinergic, and orphenadrine adds to both effects. This may cause drowsiness, confusion, constipation, urinary retention and impaired coordination.
What this interaction means in plain words
Olanzapine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression and anticholinergic effects.
What to do
Monitor for oversedation and anticholinergic effects, particularly in older adults. Reduce doses if daytime impairment or confusion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine and Orphenadrin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Orphenadrin
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Orphenadrin?
MediHelp rates the interaction as moderate. Olanzapine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is sedating and anticholinergic, and orphenadrine adds to both effects. This may cause drowsiness, confusion, constipation, urinary retention and impaired coordination.
How serious is the interaction between Olanzapine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, particularly in older adults. Reduce doses if daytime impairment or confusion develops.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
