Drug interactions
Olanzapine + Oxymorphone
Severity: Moderate
Olanzapine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is sedating and can cause orthostatic hypotension, which can add to oxymorphone's CNS and respiratory depression. Elderly patients are at higher risk of falls and oversedation.
What this interaction means in plain words
Olanzapine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Start with reduced doses and titrate carefully, monitoring sedation, blood pressure and respiratory rate. Take fall precautions in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Oxymorphone?
MediHelp rates the interaction as moderate. Olanzapine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is sedating and can cause orthostatic hypotension, which can add to oxymorphone's CNS and respiratory depression. Elderly patients are at higher risk of falls and oversedation.
How serious is the interaction between Olanzapine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses and titrate carefully, monitoring sedation, blood pressure and respiratory rate. Take fall precautions in older adults.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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