Drug interactions
Olanzapine + Procarbazine
Severity: Moderate
Olanzapine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibitory activity and may increase serotonergic and CNS effects when combined with antipsychotics. Procarbazine also has CNS depressant effects that may add to olanzapine sedation.
What this interaction means in plain words
Olanzapine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition by procarbazine with additive CNS depression and possible serotonergic effects; mechanism not fully established.
What to do
Monitor for excessive sedation, agitation, hyperthermia, rigidity and autonomic instability. Reduce the olanzapine dose if sedation is marked.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Olanzapine with Procarbazine?
MediHelp rates the interaction as moderate. Olanzapine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibitory activity and may increase serotonergic and CNS effects when combined with antipsychotics. Procarbazine also has CNS depressant effects that may add to olanzapine sedation.
How serious is the interaction between Olanzapine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, agitation, hyperthermia, rigidity and autonomic instability. Reduce the olanzapine dose if sedation is marked.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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