Drug interactions
Olanzapine + Propafenone
Severity: Moderate
Olanzapine and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has a small effect on the QT interval, while propafenone slows cardiac conduction and is proarrhythmic. The combination may modestly raise arrhythmic risk. Propafenone has little effect on olanzapine because it is cleared mainly by CYP1A2 and glucuronidation.
What this interaction means in plain words
Olanzapine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and conduction.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities. Monitor the QTc and watch for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Propafenone?
MediHelp rates the interaction as moderate. Olanzapine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has a small effect on the QT interval, while propafenone slows cardiac conduction and is proarrhythmic. The combination may modestly raise arrhythmic risk. Propafenone has little effect on olanzapine because it is cleared mainly by CYP1A2 and glucuronidation.
How serious is the interaction between Olanzapine and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities. Monitor the QTc and watch for palpitations or syncope.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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