Drug interactions
Olanzapine + Ramelteon
Severity: Minor
Olanzapine and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is markedly sedating and may add to ramelteon's drowsiness. Impaired alertness and orthostatic dizziness may occur.
What this interaction means in plain words
Olanzapine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olanzapine belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Additive CNS depression from melatonin receptor agonism and H1 and other receptor blockade by olanzapine.
What to do
Counsel about drowsiness and monitor for excess sedation. No routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Ramelteon?
MediHelp rates the interaction as minor. Olanzapine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olanzapine is markedly sedating and may add to ramelteon's drowsiness. Impaired alertness and orthostatic dizziness may occur.
How serious is the interaction between Olanzapine and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about drowsiness and monitor for excess sedation. No routine dose adjustment is needed.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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